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This may sound obvious, but you should deliver a "clean" copy to your printer for the best results. Make sure there are no pieces sticking up off the page, and that all pasting/correction materials have been removed. All elements should be securely pasted down (especially corners!) and all traces of rubber cement, wax, glue, etc. gently taken off. You might even want to go to the extra measure of taping a clean sheet of tracing paper over the entire page for protection.
(If you have used wax, be sure to keep your flats out of the sun! Try transporting them in a shallow-covered box.)